Changing the way we treat skin
Tience® patented approach mimics the body’s natural functions by capturing the self-healing capabilities of human adipose tissue. It’s tissue science, advanced through a groundbreaking technology where bioactive proteins are extracted from the liposuction fat of carefully selected donors.
As a very active tissue with an immense capacity to heal and as an excellent source of bioactive proteins, fat tissue is the cornerstone of Tience®. The balanced composition of bioactive proteins and peptides – including skin structural proteins such as collagen, ceramides and antioxidants such as tretinoin – accelerate the regeneration of skin and subcutaneous tissue, resulting in long-term improvement of skin quality and less visible skin defects.
A thoroughly researched innovation
Based on comprehensive research, Tience® is safe. No significant adverse events or adverse reactions are found to be associated with the product. Immunological risks are minimal since Tience® doesn’t contain cells. Proteins are unaltered, at physiological concentrations, not enriched and with no excipients added. As Tience® is of human origin and free of additives, it is unlikely to induce any hypersensitivity or allergic reactions and is considered safe to use. Tissue donations are voluntary, carefully screened and tested. The production process is performed under a quality management system and within a licensed tissue establishment audited by the local competent authority.
Human adipose tissue extract induces angiogenesis and adipogenesis in vitro. Sarkanen JR, Kaila V, Mannerström B, Räty S, Kuokkanen H, Miettinen S, Ylikomi T. Tissue Eng Part A. 2012 Jan; 18 (1-2): 17-25.
Adipose tissue extract shows potential for wound Healing: in vitro proliferation and migration of cell types contributing to wound healing in the presence of adipose tissue preparation and platelet rich plasma. López JF, Sarkanen JR, Huttala O, Kaartinen IS, Kuokkanen HO, Ylikomi T. Cytotechnology. 2018 Aug; 70 (4): 1193-1204.
Cytokine-Rich Adipose Tissue Extract Production from Water-Assisted Lipoaspirate: Methodology for Clinical Use. Lopez J, Huttala O, Sarkanen JR, Kaartinen I, Kuokkanen H, Ylikomi T. Biores Open Access. 2016 Sep 1;5(1):269-78.
Bioactive acellular implant induces angiogenesis and adipogenesis and sustained soft tissue restoration in vivo. Sarkanen JR, Ruusuvuori P, Kuokkanen H, Paavonen T, Ylikomi T. Tissue Eng Part A. 2012 Dec; 18 (23-24): 2568-80.
Adipose tissue as a source of growth factors to promote wound healing: a human study of skin graft donor sites. López JF, Mikkola A, Sarkanen JR, Kaartinen IS, Kuokkanen HO, Ylikomi T. Wound Care. 2022 Apr 2;31(4):282-292. doi: 10.12968/jowc.2022.31.4.282. PMID: 35404698.
Mitä kauneuskirurgia on? Asko Salmi, Esa Saarinen. Duodecim 2017;133(22):2137-44
Research report. Leppänen Minna, Kipar Anja, Mäkelä Tiina, Sarkanen Jertta-Riina, Ylikomi Timo. Pre-clinical safety evaluation of bioactive adipose tissue extract – long term repeated dose systemic toxicity study. Clinical Investigation Report (Clinius CRO) 17.3.2023, Investigation site Terveystalo Oy Ruoholahti unit. Safety study evaluating the safety and tolerability of the Liponovo tissue product in healthy volunteers
Sarkanen Jertta-Riina, 2012: Engineering vascularized soft tissue Huttala Outi, 2019: Human In Vitro Vascularization, Adipocytes and Vascularized Adipose Tissue: Three relevant models for studies of vascularization, adipocytes and their interaction. Lopez Jenny, 2020: Adipose tissue extract induces wound healing