The science

Changing the way we treat skin

Tience® patented approach mimics the body’s natural functions by capturing the self-healing capabilities of human subcutaneous tissue. It’s tissue science, advanced through a groundbreaking technology where bioactive components are obtained from carefully selected tissue donors.

As a very active tissue with immense regenerative properties, subcutaneous tissue is the cornerstone of Tience. The balanced composition of bioactive components – including structural, protective, and cell-stimulating proteins, peptides, lipids, and antioxidants – accelerate skin regeneration, resulting in long-term improvement of skin quality and less visible skin defects.
Skin regeneration

Unique effects to skin functions

Tience® activates skin cells, which improves the overall functionality of the skin.


Promotes renewal of the epidermis, which improves skin texture. Introduces lipids to the skin and supports their natural formation, maintaining a healthy skin barrier and improving moisture retention.


Improves skin regeneration by stimulating the natural production of collagen and hyaluronic acid by skin cells.


Activates microvascularization. Oxygen and nutrients are delivered to skin cells, which are essential for skin renewal.


A thoroughly researched innovation

Safety is the foundation of our product, supported by extensive long-term research. The production of Tience is performed under a quality system monitored by Fimea, and product safety is constantly observed at different stages of the manufacturing process. Tissue donations are voluntary, carefully screened, and tested.

Research, testing, and quality assurance are constantly conducted, ensuring the safety of Tience throughout the manufacturing process and in the final product. The final product, a result of the unique patented production technology, contains effective biomolecules isolated from tissue and is free from cells or additives. Based on comprehensive research, no adverse effects are found to be associated with the use of Tience.


Key publications

Human adipose tissue extract induces angiogenesis and adipogenesis in vitro. Sarkanen JR, Kaila V, Mannerström B, Räty S, Kuokkanen H, Miettinen S, Ylikomi T. Tissue Eng Part A. 2012 Jan; 18 (1-2): 17-25.

Adipose tissue extract shows potential for wound Healing: in vitro proliferation and migration of cell types contributing to wound healing in the presence of adipose tissue preparation and platelet rich plasma. López JF, Sarkanen JR, Huttala O, Kaartinen IS, Kuokkanen HO, Ylikomi T. Cytotechnology. 2018 Aug; 70 (4): 1193-1204.

Cytokine-Rich Adipose Tissue Extract Production from Water-Assisted Lipoaspirate: Methodology for Clinical Use. Lopez J, Huttala O, Sarkanen JR, Kaartinen I, Kuokkanen H, Ylikomi T. Biores Open Access. 2016 Sep 1;5(1):269-78.

Bioactive acellular implant induces angiogenesis and adipogenesis and sustained soft tissue restoration in vivo. Sarkanen JR, Ruusuvuori P, Kuokkanen H, Paavonen T, Ylikomi T. Tissue Eng Part A. 2012 Dec; 18 (23-24): 2568-80.

Adipose tissue as a source of growth factors to promote wound healing: a human study of skin graft donor sites. López JF, Mikkola A, Sarkanen JR, Kaartinen IS, Kuokkanen HO, Ylikomi T. Wound Care. 2022 Apr 2;31(4):282-92.

Mitä kauneuskirurgia on? Asko Salmi, Esa Saarinen. Duodecim 2017;133(22):2137-44

Scientific reports

Research report. Leppänen Minna, Kipar Anja, Mäkelä Tiina, Sarkanen Jertta-Riina, Ylikomi Timo. Pre-clinical safety evaluation of bioactive adipose tissue extract – long term repeated dose systemic toxicity study.

Clinical Investigation Report (Clinius CRO) 17.3.2023, Investigation site Terveystalo Oy Ruoholahti unit. Safety study evaluating the safety and tolerability of the Liponovo tissue product in healthy volunteers.

PhD Studies

Sarkanen Jertta-Riina, 2012: Engineering vascularized soft tissue

Huttala Outi, 2019: Human In Vitro Vascularization, Adipocytes and Vascularized Adipose Tissue: Three relevant models for studies of vascularization, adipocytes and their interaction.

Lopez Jenny, 2020: Adipose tissue extract induces wound healing.